There Is Strong Evidence That Ephedra Effects Increased Risk Of Side Effects, Possibly Even Fatal Ones

nih gov, Mar 11, 2005

NCCAM supported a study of calls to poison control centers that revealed a disproportionate rate of reactions to ephedra relative to other herbal products. NCCAM will support to their completion two ongoing laboratory studies to better understand the mechanism of action and chemical properties of ephedra:

Pharmacology of Combined Ephedrine/Caffeine Supplements (University of California, San Francisco)
Effects of Ephedra on Human Adrenoceptor Subtypes (University of Mississippi)

NCCAM will not fund any new studies of existing ephedra-containing products.

What is covered by these actions?
Essentially all currently marketed dietary supplements that contain a source of ephedrine alkaloids, such as ephedra, ma huang, Sida cordifolia, and pinellia, are affected by this rule. The rule does not pertain to traditional Chinese herbal remedies. It generally doesn't apply to products like herbal teas that are regulated as conventional foods. In addition, products regulated as drugs that contain chemically synthesized ephedrine are not dietary supplements and not covered by this rule. These include drugs used for the short-term treatment of asthma, bronchitis, and allergic reactions.

There is strong evidence that ephedra is associated with an increased risk of side effects, possibly even fatal ones. There is no evidence that ephedra products enhance athletic performance. There is little evidence of any benefit except for short-term weight loss. Taken together, the FDA recommends that consumers immediately stop using dietary supplements containing ephedra or ephedrine alkaloids.

While respecting the traditional uses of herbal medicines, their long history of use, and their potential health benefits, NCCAM believes that ephedra poses unique public health risks that warrant the FDA's actions to prohibit the sale of ephedra-containing dietary supplements.

Consumers need to be informed of the potential risks and benefits of herbal products. It is best to discuss use of herbal products with one's health care provider.