Prempro is the hormone therapy given to women who are menopausal. It is supposed to reduce the symptoms, including hot flashes, night sweats, mood swings, and more. Prempro is also supposed to help prevent thinning of the bones that result in hip fractures. However, it is not without significant risks. Women who take Prempro are more likely to develop breast cancer, blood clots, heart disease, and strokes. The side effects can also include abnormal vaginal bleeding, headaches, white vaginal discharge, itching, and irritation. In short, before taking any hormone replacement therapy, you need to discuss your personal circumstances with your doctor. You will have to determine if the benefits are greater than the potential risks.