Acetaminophen hydrocodone is a combination of two medications to relieve moderate to severe pain. Acetaminophen is the stuff that Tylenol is made of, and hydrocodone is a stronger narcotic to get the pain under control. Think of the acetaminophen as a pain relief booster. However, both are not without risks. Acetaminophen can be very harmful for those that have liver disease or have more than 3 drinks per day. Hydrocodone can be addictive, so it is important to take it only as directed, and not to make a habit of using the painkiller. It is not meant for permanent use. You doctor should only prescribe the medication for a short period of time. It is not for long-term pain relief.