Like almost every other medication on the market today, whether it is prescription or over the counter, acetaminophen and alcohol can be a dangerous combination. You could suffer from alcohol-acetaminophen syndrome or other life-threatening complications. Your body needs your liver to metabolize the alcohol in your system. Simultaneously, acetaminophen also needs your liver to break down and do its job. In essence, you liver cannot handle the combined expectations and it can result in irreversible liver damage. Even moderate drinkers are at risk for acute liver failure. You cannot live without this organ. If you are concerned whether your liver can handle acetaminophen and you alcohol habits, you need to consult your doctor.